• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    DISPENSER FOR LIQUIDS. The present invention relates to a dispenser for discharging a pharmaceutical or cosmetic medium. Dispensers for discharging a pharmaceutical or cosmetic medium are known with a discharge head (110) having a discharge opening (124) and with a container (1) for storing the free-flowing medium before discharging, which comprises an external container elastically deformable (2) and a dimensionally flexible inner container (3), which receives the medium and which is disposed in an interior of the outer container (2). A ventilation channel (4) is provided, through which the interior of the external container (2) is connected to an environment for the purpose of compensating a pressure by means of make-up air. According to the invention, it is proposed that the ventilation channel (4) is delimited in at least some regions by a label (8), in particular a label (8) which is self-adhesive in at least some regions and that the channel ventilation (4) is designed in at least some regions as a capillary channel, with the capillary channel (4) preferably having a minimum cross-sectional surface area that is less than 1 mm 2 and the length quotient of the capillary channel and (...).
    公开号:BR112015031386B1
    申请号:R112015031386-8
    申请日:2014-05-08
    公开日:2021-05-18
    发明作者:Matthias Wochele
    申请人:Aptar Radolfzell Gmbh；
    IPC主号:
    专利说明:

    FIELD OF USE AND PRIOR TECHNIQUE
    [0001] The present invention relates to a dispenser for discharging a free-flowing pharmaceutical or cosmetic medium, with a discharge head having an opening for discharge and with a container for storing the free-flowing medium before discharging. The container has an outer container and an inner container arranged inside the latter. The outer container is elastically deformable, which is to be understood as meaning that a user can press it in the manner of a squeezing bottle, in order to reduce its internal volume and thus discharge the liquid. outer container returns to its initial shape after force stops being applied. The inner container arranged in the outer container is the part of the container that directly receives the medium. Between this inner container and the outer container, a free space is provided that becomes small as the inner container is gradually emptied, as the outer volume of the inner container decreases as the medium is removed, while the inner volume of the outer container remains constant .
    [0002] In order to prevent an underpressure from rising in this free space and causing problems in the operation of the dispenser, a vent channel is provided in the dispensers of the type in question and connects the interior of the outer container to a surrounding atmosphere for the purpose of pressure compensation by means of compensation air.
    [0003] After a discharge has occurred, said vent channel allows air from the environment to be sucked into said free space, so that it is more or less at atmospheric pressure which then once again prevails in the container. However, the vent channel is also problematic in principle, as with the outer vessel it is pressed as intended for the purpose of accumulating pressure in the inner vessel and therefore for the discharge purpose it counteracts the build-up of pressure. The slower the actuation when pressing the outer container, the more air can escape out through the vent channel and therefore reduce the amount of medium that must be discharged, as the pressure in the headspace does not build up to the desired level.
    [0004] In document No. EP 1 985 543 A2, which refers to matter of the generic type, this problem is neutralized by the ventilation channel that is intended to be closed by the user, using one of his fingers, during the acting. However, this makes manipulation more difficult. PROBLEM AND SOLUTION
    [0005] The problem solved by the invention is that of providing a technical solution through which it is possible to create in a simple way a ventilation channel whose flow resistance is dimensioned so that, when the external container is pressed, a pressure necessary to discharge the medium can accumulate in the inner container.
    [0006] According to the invention, this problem is solved by the use of a label on the dispenser, and the label influences the flow resistance in the ventilation channel in order to increase it.
    [0007] According to the invention, this ventilation channel, which should also be understood as a simple ventilation opening, is delimited in at least some regions by said label, which in particular is preferably designed as a self-adhesive label. As already mentioned, the label provides the vent channel with a flow resistance that is high enough to allow the pressure necessary for the discharge to build up in the inner vessel.
    [0008] The at least regional delimitation of the ventilation channel by a self-adhesive label in particular should be understood as meaning that the label is applied, so that, by application, it increases the flow resistance, according to In the first aspect of the invention, a free path for air remains macroscopically revealed by the label. Various types of application for this purpose are explained in more detail below. In general, it is considered advantageous if the label is applied on the outside of a surface accessible from outside the dispenser, in particular on said external container.
    [0009] The use of a label is particularly advantageous since it allows the flow resistance to be influenced in a simple way and, through the choice of label and the place of application thereof, it is possible to influence the characteristics of the flow channel. ventilation according to the specific purpose of its use. Furthermore, it is advantageous if the label not only serves to influence the flow resistance, but at the same time also constitutes an indescribable label that carries user information, in particular the name of the dispenser or cosmetic or pharmacist manufacturer, instructions for use, composition of the contents of the dispenser and so on.
    [0010] The label used in said context is a thin film-like surface portion with a thickness of less than 300 µm, preferably less than 200 µm. This label is applied to a surface and acts on it to influence the flow resistance of the vent channel. It is preferably a self-adhesive label. Arrangements are also conceivable in principle in which the adhesive for applying the label is applied separately to said surface before applying the label, but a self-adhesive arrangement is advantageous. In individual cases, other methods of applying the label may also be advantageous, for example, circumferential shrink fit labels or labels that are welded or otherwise thermally secured.
    [0011] The outer container can, for example, be in the form of a bottle or a tube. It is in particular releasably connected to a discharge head in which the discharge opening is provided. The latter is preferably closed, before actuation of the dispenser, by a valve that opens depending on pressure.
    [0012] In one embodiment, a channel portion of the vent channel formed together by an extended groove-like recess in a channel component is provided, with the channel component again preferably being the outer container and the label is applied to the channel member, so that the channel portion is circumferentially closed by the recess and the adhesive label.
    [0013] There is therefore provided a groove which can be made, in particular, on an outer face of the outer container and which is supplied by the applied label to form a circumferentially closed channel. The flow resistance of the vent channel can therefore easily be increased. If a particularly high flow resistance is desired, the cross-section of the recess is chosen as being very small. Alternatively, or in addition, a particularly long recess can also be used which, for example, can also be obtained by a helical or spiral-shaped configuration of the vent channel. The entrance with ambient side of the vent channel is formed by the end of the channel portion that is generated together by the recess and the label.
    [0014] As already mentioned, the vent channel or the vent opening is configured in particular so that the associated flow resistance is such that, when the outer container is pressed, a pressure sufficient to discharge the medium builds up in the inner container. This is preferably achieved by the fact that the vent channel has a flow resistance that is sufficiently high so that the volumetric flow rate does not exceed 0.2 ml/s at a pressure difference of 70 kPa (700 mbar) between the external container and the environment. It has been observed that such a flow resistance, which at an absolute internal pressure of approximately 170 kPa (1.7 bar) relative to an atmospheric pressure of approximately 100 kPa (1 bar) allows only 0.2 ml/s to flow out of the space between inner container and outer container and does not negatively influence custom performances. As an approximation and without taking into account the change in influencing factors, an overpressure in the free space between the inner and outer vessel in relation to the surrounding atmosphere of 70 KPa (0.7 bar) therefore leads to a loss of 1 ml maximum air of the free space between the inner cup and the outer cup at an actuation time of 5 seconds.
    [0015] However, a flow resistance that is too high is also undesirable as this would greatly increase the length of time required for pressure compensation. In order to be able to use the dispenser again quickly at customary intervals, in particular after 15 to 30 seconds, for example to discharge some batches into a drop dispenser, it is advantageous if the volumetric flow rate is 0.2 ml/s in a pressure difference of 20 kPa (200 mbar).
    [0016] Overall, therefore, a vent channel configuration is advantageous that allows a volumetric flow rate of 0.2 ml/s at a pressure difference between 20 kPa (200 mbar) and 70 kPa (700 mbar) . It should be noted, however, that the flow resistance for the inflow of air into the headspace and the outflow of air out of the headspace need not be identical depending on the geometry of the vent channel. In general, the flow resistance of the vent channel is configured so that, with an outflow of air at 0.2 ml/s, an overpressure of 70 kPa (700 mbar) must be present and/or that it stops the flow. of air inlet at 0.2 ml/s, a sub-pressure of 20 kPa (200 mbar) must be present.
    [0017] It is particularly advantageous, in particular to achieve the preferred flow resistance indicated above, that the ventilation channel is designed in at least some regions as a capillary channel. The latter has a minimum cross-sectional surface area that is less than 1 mm2. It is particularly advantageous if the quotient of the length of the capillary channel and the mean cross-sectional surface area of the capillary channel is greater than 200 mm-1 in the region in which the cross-sectional surface area is less than 1 mm2.
    [0018] The use of a label, in particular a self-adhesive label, can occur as described above, so that the label influences the flow resistance of the vent channel in such a way that the length of the latter is influenced or the area of minimum cross-sectional surface of it is influenced.
    [0019] In advantageous embodiments, the dispenser is designed as a drop dispenser, in particular as an eye drop dispenser. It is a dispenser, particularly a drop dispenser, for dispensing medications containing liquid formulations of groups of molecules commonly used in ophthalmology (treatment of increased intraocular pressure, treatment of glaucoma, treatment of dry eyes, treatment of allergies and inflammation). These groups of molecules are in particular alpha-2-agonists (eg brimonidine), prostaglandin analogues (eg tafluprost, latanoprost, bimatoprost, travoprost), beta blockers (eg timolol) and anhydrase inhibitors carbonic acid (eg dorzolamide), in addition to hyaluronic acid compounds, film-formers in general (eg methylcellulose compounds) and cyclosporine and also antihistamines (eg olopatadine and levocabastin), steroids ( eg loteprednol and dexamethasone) and also NSAIDs (eg ketorolac). BRIEF DESCRIPTION OF THE FIGURES
    [0020] Additional aspects and advantages of the invention will be evident from the claims and the following description of the exemplary embodiments of the invention, which are exemplified with reference to the Figures in which:
    [0021] Figure 1 shows a dispenser that is provided according to the invention with an outer container and an inner container,
    [0022] Figures 2A to 2D show the outer container and the inner container of a first embodiment of a dispenser according to the invention,
    [0023] Figure 3A shows a variation of the container in relation to Figures 2A to 2D.
    [0024] DETAILED DESCRIPTION OF ILLUS TRATIVE MODALITIES
    [0025] Figure 1 shows a dispenser according to the invention in a sectional view. The vent channel provided here on the dispenser in Figure 1 is to be understood as an example only. Different vent channel configurations are set out in detail below.
    [0026] The dispenser according to the invention as shown in Figure 1 has a discharge head 110, which is locked onto a container 1 by locking means 20, 120 on both sides. In a known manner, the discharge head 110 has an outlet valve 130 with a valve body 132 to which force is applied by a valve spring 134. This valve body 132 closes a discharge opening 124 by means of a valve surface 136.
    [0027] A drop forming surface 126 is provided on the outer side of the discharge opening 124. A valve space 128 is provided between the valve body 132 and an inner face of the discharge head housing 110. an upward position in which the discharge head 110 points downwards, the liquid in the container 1 is subjected to pressure by manual compression of the container 1, this also leads to a pressure increase in the valve space 128. In response to this, the valve body 132 is moved against the force of the valve spring 134 and releases a path of liquid to the discharge opening 124. This then causes the liquid to be discharged.
    [0028] The dispenser here is designed as a drop dispenser and is therefore provided with the above-mentioned drop forming surface 126. The liquid flowing out through the discharge opening 124 is collected on this drop forming surface until that it stands out in the form of a drop from it.
    [0029] The modality as a gout dispenser should be understood as an example. Other types of dispensers, for example those which generate a spray jet, can also be configured in the manner according to the invention.
    [0030] Container 1 has multiple layers. It has an outer container 2 made of an elastic plastic and forming a squeezing bottle. This means that, in order to discharge liquid in the intended manner, the outer container 2 is pressed, for example, with a force between 5 N and 20 N. When this force runs out, the outer container returns immediately or after a short interval to the initial shape thereof shown in Figure 1. An inner container 3 is disposed within the outer container 2. This inner container 3 is a dimensionally flexible bag provided to hold the liquid that is to be discharged. This is preferably a pharmaceutical or cosmetic liquid, in the present case in particular a medicine which is to be administered in the form of eye drops. In contrast to the outer container 2, the bag-like inner container 3 is not intended to increase in volume again after completion of the discharge procedure. Instead, a reduction in the volume of the inner container is provided as the dispenser is progressively emptied, without this causing observable restorative forces on the walls of the inner container.
    [0031] An increase in volume of the free space 9 between the outer container 2 and the inner container 3 is therefore provided while the dispenser is progressively emptied. If this free space were isolated from a surrounding atmosphere, an underpressure would rise and suppress the discharge of liquid well before the medium in inner vessel 3 is used.
    [0032] To allow pressure compensation in free space 9, a vent opening/vent channel 4 is provided. This connects free space 9 to a surrounding atmosphere. However, since this pressure compensation would mean that, with the inner container 3 already partially emptied, an overpressure required for the discharge would not be able to accumulate in the free space in the actuation, the vent channel 4 is configured so that it has a sufficiently high flow resistance to allow effortless discharge in any way.
    [0033] The question of how high this flow resistance should be depends on numerous factors, for example, the internal volume of the outer container and the inner container. Particularly, in normal-sized drop dispensers, which in most cases have an internal volume of approximately 10 ml, it is considered expedient if the flow resistance of the vent channel is such that, at an overpressure of 70 kPa ( 700 mbar) in the free space between outer vessel 2 and inner vessel 3, no more than 0.2 ml/s flow out through the vent channel 4. In addition, the desired flow resistance also depends on the force with which it is intended to press the outer container 2 together and the middle which is discharged. Additional influences are the intended duration of actuation and the anticipated time interval between two discharge procedures.
    [0034] The views in Figures 2A to 3A show various embodiments of the container 1 that are designed to achieve such flow resistance.
    [0035] In the embodiment in Figures 2A to 2D, the outer container 2 is provided which is breached by a comparatively large through opening 21. This through opening leads to an undercut 7, which extends in the axial direction away from the outer container 2 To ensure that the air flowing out during dispenser actuation can only flow out against a high flow resistance, the groove type recess 7 is closed mostly closed by an adhesive label 8 or shrink fit label 8 In this mode, therefore, in the channel portion provided outside the outer container, the ventilation channel is circumferentially delimited on the one hand by the outer container 2 and on the other hand by the inner face of the label 8. A very simple possibility it is therefore allowed to create a long vent channel of high flow resistance. Additionally, by varying the size of the label, it is also possible to adjust the desired flow resistance in a simple way.
    [0036] It will be observed from Figure 3A that, through a non-linear extension of the groove type 7 lowering, it is possible to achieve a greater extension of the outer portion of the ventilation channel 4. In the variation according to Figure 3A, it is a groove-type helical undercut 7 which is partially closed around the circumference by the label 8.
    [0037] The label 8 is preferably provided which serves to increase the flow resistance, but at the same time it is a label of the type on which the information 82 to be read by the user is printed.
    权利要求:
    Claims (6)
    [0001]
    1. Dispenser for discharging a pharmaceutical or cosmetic medium, with - a discharge head (110) having a discharge opening (124) and - a container (1) for storing the free-flowing medium before discharging, which comprises - an elastically deformable outer container (2) and - a dimensionally flexible inner container (3), which receives the medium and which is arranged in an interior of the outer container (2), in which - a ventilation channel (4 ) is provided, through which the interior of the outer container (2) is connected to an environment for the purpose of compensating a pressure by means of make-up air, - the ventilation channel (4) is delimited in at least some regions by a label (8), in particular a label (8) which is self-adhesive in at least some regions and characterized by the fact that - the ventilation channel (4) is designed in at least some regions as a capillary channel , the capillary channel (4) preferably having a surface area. minimum cross-sectional surface area that is less than 1 mm2 and where the quotient of the capillary channel length and the average cross-sectional surface area of the capillary channel is greater than 200 mm-1.
    [0002]
    2. Dispenser according to claim 1, characterized in that a channel portion of the ventilation channel (4) is formed jointly by - an extended groove-type recess (7) in a channel component (2) , wherein the channel component (2) is preferably formed by the outer container (2) and - the label (8), which is applied to the channel component (2), so that the channel portion is circumferentially closed by the lowering (7) and by the label (8).
    [0003]
    3. Dispenser according to any of the preceding claims, characterized in that the label (5, 6, 8) is printed.
    [0004]
    4. Dispenser according to any one of the preceding claims, characterized in that the ventilation channel (4) has a flow resistance that is dimensioned so that when the outer container (2) is pressed together, a pressure enough to discharge the medium can be accumulated in the outer container (2), in which the vent channel (4) for that purpose preferably has a flow resistance that is sufficiently high so that the volumetric flow rate does not exceed 0.2 ml/s at a pressure difference of 70 kPa (700 mbar) between the external container and the environment.
    [0005]
    5. Dispenser according to claim 4, characterized in that the vent channel (4) has a flow resistance that is sufficiently low so that the volumetric flow rate is not less than 0.2 ml/ s at a pressure difference of 40 kPa (400 mbar) between the outer vessel (2) and the environment.
    [0006]
    6. Dispenser according to any one of the preceding claims, characterized in that the ventilation channel (4) has a spiral or helical shape in at least some regions.
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    WO2014202278A1|2014-12-24|
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    引用文献:
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    FR2389419A1|1977-05-02|1978-12-01|Szczepanski Harry|Manually operated flowable material dispenser - has outer housing surrounding readily deformable inner container holding material to be dispensed|
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    DE10216400A1|2002-04-12|2003-10-23|Axel Mueller|Toothpaste tube comprises inner tube filled with paste and enclosed by outer tube with valve connecting it to atmosphere, so that as paste is dispensed from inner tube it is held in its compressed state|
    FR2844773B1|2002-09-24|2005-01-28|Jerome Boumnso|DEVICE FORMING A PACKAGING OF VISCOUS PRODUCTS WITH COMPLETE VIDAGE THROUGH MANUAL PUMPING|
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    JP5667010B2|2011-06-09|2015-02-12|株式会社吉野工業所|Discharge container|DE102013226253B4|2013-12-17|2016-03-24|Aptar Radolfzell Gmbh|Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids|
    KR102005246B1|2015-05-28|2019-07-30|교라꾸 가부시끼가이샤|Double container|
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    CN112173336A|2016-04-15|2021-01-05|京洛株式会社|Laminated peeling container|
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    法律状态:
    2019-12-31| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-03-30| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-05-18| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/05/2014, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102013211423.0|2013-06-18|
    DE201310211423|DE102013211423A1|2013-06-18|2013-06-18|Multilayer container|
    PCT/EP2014/059498|WO2014202278A1|2013-06-18|2014-05-08|Dispenser for liquids|
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